Pendrin as a Novel Target for Diuretic Therapy

Pendrin-A New Target for Diuretic Therapy?

A novel target for diuretic therapy.

The reabsorption of salt in the distal nephron is predominantly mediated via the thiazide-sensitive sodium chroride cotransporter, NCC (SLC12A3), and the chloride-bicarbonate exchanger pendrin (SLC26A4, PDS), with pendrin working in tandem with the epithelial sodium channel and NCC working by itself. Single deletion of NCC or pendrin in genetically engineered mouse models does not cause salt wa...

P14: Mitochondria as a Target for Drug Therapy in Epilepsy

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assessment of the effect of honey as a topical therapy for intra oral wound healing in rat.

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Chemoimmunotherapy as a Novel Cancer Therapy

Over the past decade, it was widely accepted that some chemotherapeutic drugs can be combined with immunotherapeutic drugs in treatment of cancer. Chemotherapeutic drugs can induce apoptosis in the tumor cell and at the same time stimulate the immune response. Several reports support the use   immunomodulators in treatment of cancers through regulating the immune response and boosting the micro...